A groundbreaking study led by Professor Lee Hae-shin from the Korea Advanced Institute of Science and Technology (KAIST) has revealed that tannic acid, a natural polyphenol, could reduce hair loss by up to 90%. The findings, published on January 6 in Advanced Materials Interfaces, show that tannic acid not only acts as a coating agent but also serves as an “adhesion mediator” to prevent hair loss.
Hair loss affects millions globally, driven by factors such as genetics, hormones, and environment. Current treatments like minoxidil and finasteride are effective but require long-term use and can cause side effects. Additionally, their effectiveness varies between individuals.
The KAIST research team discovered that tannic acid binds strongly with keratin, the protein found in hair, allowing it to stay attached to the hair surface. This binding property enables the gradual release of functional ingredients aimed at combating hair loss.
In their study, the researchers developed a combination of ingredients known as SCANDAL, which includes salicylic acid (SCA), niacinamide (N), and dexpanthenol (DAL). This complex, combined with tannic acid, slowly releases its active ingredients upon contact with moisture, delivering them directly to hair follicles.
A clinical trial conducted at Goodmona Clinic involved 12 participants with hair loss. After seven days of using a shampoo containing the SCANDAL complex, all subjects showed a significant reduction in hair shedding, with some experiencing up to a 90% decrease. On average, participants saw a 56.2% reduction in hair loss, further supporting the efficacy of tannic acid in stabilizing the SCANDAL complex on the hair surface for targeted delivery to the follicles.
Professor Lee explained, “Tannic acid, a powerful antioxidant, strongly binds with proteins, which proves its potential as a bioadhesive.” He also noted that the technology was applied to the ‘Grabity’ shampoo, developed by the faculty startup Polyphenol Factory. “We are working to commercialize products based on our findings, such as shampoos that enhance hair strength and products that straighten curly hair,” he added.
This research offers promising new options for individuals seeking effective solutions for hair loss.
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