A recent study has raised concerns that semaglutide, the active ingredient in the weight loss drugs Ozempic and Wegovy, may contribute to hair loss in some users. The study, published on the preprint server MedRxiv in March 2025, is the first to investigate this side effect in a real-world clinical setting, and although it has not yet been peer-reviewed, it offers compelling new insights.
Hair Loss Risk in Semaglutide Users
Researchers from the University of British Columbia (UBC) conducted a study comparing the incidence of hair loss in patients taking semaglutide for weight loss with those using bupropion-naltrexone, another weight loss medication. Their findings suggest that people using semaglutide experienced a higher rate of hair loss.
The study analyzed data from 1,926 individuals using semaglutide for weight loss and compared it to 1,348 individuals using bupropion-naltrexone. Results showed that 26.5 out of every 1,000 people on semaglutide were diagnosed with hair loss, compared to just 11.8 out of 1,000 people using bupropion-naltrexone. Notably, women taking semaglutide experienced more than double the rate of hair loss compared to men.
First author Dr. Mohit Sodhi, a researcher and emergency medicine resident at UBC, emphasized that while there have been anecdotal reports of hair loss related to semaglutide, this is the first study to examine the issue in a large clinical setting. “There were many case studies and reports to the FDA, but no studies have looked at this risk in such a real-world context,” Dr. Sodhi told Health.
Hair Loss and GLP-1 Medications
Semaglutide belongs to a class of drugs known as GLP-1 receptor agonists, which help with weight loss by mimicking the effects of a natural hormone that regulates appetite and insulin. Though the study’s findings are preliminary, other experts in the field have corroborated patient reports of hair loss associated with GLP-1 medications.
Dr. Saami Khalifian, a double board-certified dermatologist, has observed a pattern of hair loss, particularly telogen effluvium (a non-scarring form of hair loss), in patients taking GLP-1 medications like semaglutide. This condition results from a disruption in the hair growth cycle, causing increased shedding. “This rapid hair loss is common among patients on GLP-1s,” said Dr. Khalifian.
Dr. Brynna Connor, a board-certified family medicine physician, has also noticed hair loss among her patients taking GLP-1 drugs, with this being one of the top concerns next to gastrointestinal issues like constipation and diarrhea.
Potential Causes of Hair Loss
While more research is needed to confirm the exact cause, the study’s authors suggest that rapid weight loss might be the primary trigger for hair loss, rather than semaglutide itself. “Weight loss can induce physiological stress, disrupting the natural hair cycle,” Dr. Sodhi explained. “Since semaglutide is known to cause faster weight loss than other weight loss medications, it could place more stress on the body, leading to more pronounced hair loss.”
Other factors, such as nutritional deficiencies, could also play a role. GLP-1 drugs, by suppressing appetite and slowing gastric emptying, can reduce food intake, making it harder for users to get the necessary nutrients to maintain healthy hair. “If you aren’t getting enough protein and essential nutrients, your hair will suffer,” said Dr. Khalifian.
Minimizing the Risk of Hair Loss
If you’re concerned about the potential for hair loss while using GLP-1 medications, experts suggest focusing on proper nutrition. Dr. Khalifian recommends prioritizing protein in meals, as it is vital for hair growth and overall health. “Eat protein first, as it will help ensure you get the necessary nutrients before feeling too full,” he advised.
Dr. Connor suggests considering supplements, such as biotin, to promote hair health, and topical treatments like minoxidil to encourage hair regrowth. Before starting a GLP-1 drug, she also recommends getting lab work to rule out underlying conditions such as anemia or thyroid issues that could contribute to hair loss.
A Personalized Approach to Weight Loss Medications
Dr. Sodhi emphasized that the decision to use GLP-1 medications should be made with careful consideration of the individual’s health needs. “The risk-benefit calculus for someone with morbid obesity or uncontrolled diabetes is very different from someone using these medications for recreational weight loss,” he said. For those with more severe health conditions, the potential benefits of weight loss might outweigh the risks of side effects like hair loss.
If you’re experiencing hair loss or other side effects while on GLP-1 medications, it’s important to consult with your healthcare provider. A personalized approach, including working with a dietitian and considering supplemental treatments, can help minimize side effects while maximizing the benefits of weight loss.
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